The Partnership for Advancing Clinical Electronic Research (PACeR) is a collaborative of leading health care and biopharmaceutical organizations, New York State medical centers, and technology companies that is developing tools, business models, and processes to advance clinical research. A key component of this effort is leveraging existing and new types of clinical care data in scientific research by engaging and connecting patients, physicians, and institutions throughout the research process. Initial applications include clinical trial modeling, patient identification for clinical trials, and safety/outcomes monitoring. PACeR is currently conducting its first four enrollment acceleration projects for real-world clinical studies, leveraging clinical care data, referral networks, and patient information and screening portals. The PACeR team also features an advisory board consisting of government agencies, standards bodies, patient advocates, and bio-ethicists. Sponsoring members include Bayer, Johnson & Johnson, Merck, Oracle, Pfizer, Quintiles, and Roche. The Healthcare Association of New York State (HANYS) and fifteen major New York medical center networks were additional founding members, and an additional eleven sites have since become involved through recent projects.